NPTEL Organ Printing Week 6 Assignment Answers 2023

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NPTEL Organ Printing Week 6 Assignment Solutions

NPTEL Organ Printing Week 6 Assignment Answers 2023

1. In the context of bioprinting a functional heart tissue, which parameter is more critical, cellular alignment, vascularization or proper synchronization of electrical impulses and contractility? Justify your choice.

  • Cellular alignment; it enables uniform electrical propagation and coordinated contractions
  • Vascularization; it provides nutrient supply but doesn’t significantly affect electrical coupling
  • Both are critical and electrical synchronization and contractility is dependent on them
  • Electrical synchronization and contractility is considered of utmost importance
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2. Consider the integration of cardiomyocytes and endothelial cells in a bioprinted cardiac construct. Which cellular ratio is more conducive to functional heart tissue?

  • High cardiomyocyte-to-endothelial cell ratio; it enhances contractile strength and tissue robustness
  • Balanced ratio; it promotes vascularization and oxygen diffusion, crucial for tissue survival
  • Both ratios are equally functional; tissue performance is independent of individual cell composition
  • Cellular ratio is irrelevant in bioprinting heart tissue; construct functionality is predetermined
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3. In the bioprinting of kidney tissue, which is more challenging to replicate: the structural complexity of nephrons or the intricate filtration processes within glomeruli?

  • Structural complexity of nephrons; glomerular filtration processes are relatively standardized
  • Intricate filtration processes within glomeruli; nephron structures are relatively uniform
  • Both challenges are equally formidable; one cannot be more challeging over the other
  • Neither aspect poses significant challenges; kidney bioprinting is inherently simplified
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4. When designing a bioink for bioprinting liver tissue, which property is more crucial that supports hepatocyte metabolic functions?

  • Mechanical stiffness resembling native liver; it maintains tissue integrity and vascular stability
  • Dynamic microenvironment; it ensures hepatocytes’ metabolic responsiveness and function
  • Both properties are equally important; one cannot be prioritized without compromising the other
  • Neither property significantly influences liver tissue function; cell behaviour dominates outcomes
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5. In the bioprinting of lung tissue, the integration of mechanical stretch simulation during tissue maturation can enhance tissue elasticity and mimic physiological breathing motions. How does the inclusion of mechanical stretch affect cell alignment, ECM remodelling, and tissue contractility within the bioprinted lung construct?

  • Mechanical stretch enhances cell alignment and ECM remodelling but might hinder tissue contractility
  • Mechanical stretch optimizes tissue contractility and ECM remodelling but may not significantly impact cell alignment in the bioprinted construct
  • Balancing mechanical stretch simulation optimizes cell alignment, ECM remodelling, and tissue contractility
  • Mechanical stretch simulation has minimal impact on cell alignment, ECM remodelling, and tissue contractility within the bioprinted lung construct
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6. Discuss the potential role of ALI culture in promoting the development of functional respiratory epithelium within the bioprinted lung tissue.

  • The establishment of an air-exposed environment enhances secretory cell differentiation and mucociliary clearance mechanisms in bioprinted constructs
  • ALI culture disrupts secretory cell differentiation and mucociliary clearance mechanisms, leading to compromised lung tissue functionality
  • ALI culture introduces imbalanced cellular composition and variability between ciliated and non-ciliated cells
  • The impact of ALI culture on secretory cell differentiation, but not mucociliary clearance mechanisms, has critical influence on lung tissue functionality
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7. Arrange the following organs based on the challenges of bioprinting –

  • Heart > Liver > Lung > Kidney
  • Kidney > Liver > Heart > Lung
  • Lung > Heart > Liver > Kidney
  • Kidney > Heart > Liver > Lung
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8. Kenzan Method Bioprinting requires –

  • Cells + Matrix
  • Cell + Media
  • Cells + Bioactive Factor
  • All of the above
  • None of the above
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9. The total surface area of Lung alveolar space –

  • 100 m2
  • 1 m2
  • 100 cm2
  • None of the above
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10. Proximal tubule bioprinting is important for –

  • Heart
  • Kidney
  • Lung
  • Liver
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11. Epithelial- Endothelial barrier present in –

  • Kidney
  • Lung
  • None of the above
  • All of the above
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12. What cell types are the unique to Heart tissue –

  • Hepatocytes
  • Fibroblasts
  • Cardiomyocytes
  • None of the above
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13. The major resident cells of liver are –

  • Smooth Muscle cells
  • Keratocytes
  • Hepatocytes
  • All of the above
  • None of the above
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14. The major function of glomerulus In Kidney –

  • Cellular differentiation
  • Autonomous self-assembly
  • Filtration of blood
  • None of the above
  • All of the above
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15. What kind of bioink is suitable for printing liver acinus –

  • High viscous
  • Low viscous
  • Moderate viscous
  • All of the above
  • None of the above
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Course NameOrgan Printing
CategoryNPTEL Assignment Answer
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